Birmingham is a city in the north central region of the U.S. state of Alabama. Birmingham is the seat of Jefferson County, Alabama’s most populous county. As of 2020, Birmingham had a population of 200,733, making it Alabama’s second-most populous city after Huntsville. The broader Birmingham metropolitan area had a 2020 population of 1,115,289, and is the largest metropolitan area in Alabama as well as the 50th-most populous in the United States. Birmingham serves as an important regional hub and is associated with the Deep South, Piedmont, and Appalachian regions of the nation.